The effect of eating behaviour upon BMI in women with gestational diabetes

Aims: Gestational diabetes has been attributed to maternal obesity and suboptimal maternal diet but the relative contribution of maternal eating behaviour is unknown. We compared eating behaviour in women with gestational diabetes and non-pregnant adults, and assessed which eating behaviour traits were most strongly associated with BMI in women with gestational diabetes. Method(s): Participants (total n = 448) including men (n = 67), non-pregnant women (n = 181) and women with gestational diabetes during a singleton pregnancy (n = 200;29 weeks' gestation;NICE / Covid-19 criteria) were recruited prospectively and completed a three-factor eating questionnaire (TFEQ-R18). Associations between BMI and uncontrolled eating (UE), emotional eating (EE) and cognitive restraint (CR) were assessed using linear regression. Result(s): Women with gestational diabetes had significantly lower UE scores compared to men (53% vs 63%;p < 0.001) and non-pregnant women (53% vs 65%;p < 0.001), and lower EE scores compared to non-pregnant women (60% vs 70%;p < 0.001). In men, BMI showed positive associations with UE (Coeff 25.2;95% CI 10.8-39.6;p = 0.001) and EE scores (Coeff 11.9;95% CI 3.3-20.6;p = 0.007) while CR had no significant association. In non-pregnant women, BMI showed positive associations with UE (Coeff 20.7 95% CI 11.4-30.0), p < 0.001) and EE scores (Coeff 7.7;95% CI 1.8-13.6;p = 0.010) and negative associations with CR (Coef-10.6;95% CI -21.1 to -0.1;p = 0.049). In women with gestational diabetes, only EE scores were significantly associated with BMI (Coeff 7.8;95% CI 3.9-11.7;p < 0.001). Conclusion(s): Women with gestational diabetes have favourable eating behaviour compared to men and non-pregnant women. Addressing EE may provide new translational opportunities to reduce BMI in gestational diabetes.

Optimal continuous glucose monitoring metrics for identification of women with gestational diabetes

Aims: Continuous glucose monitoring (CGM) is widely used in pregnant women with pre-gestational diabetes, but optimal targets have not been defined in gestational diabetes. Previous work identified mild hyperglycaemia in pregnant women without gestational diabetes, but with risk factors such as obesity. We aimed to examine CGM metrics and patterns of glycaemia in women with gestational diabetes compared to healthy pregnant women with comparable risk factors. Method(s): We recruited 73 healthy women with >1 risk factor (gestational diabetes excluded using Covid-19 criteria, OGTT) and 200 women with gestational diabetes (NICE and interim-Covid- 19 criteria) from antenatal clinics at 28 weeks' gestation. A Dexcom G6 CGM device was cited on the non-dominant upper arm. Result(s): Women with gestational diabetes had significantly higher weight (mean +/- SEM 95.7 kg +/- 1.3 Vs 85.4 kg +/- 2.2) and BMI (36.0 +/- 0.5 Vs 31.3 +/- 0.7) compared to healthy pregnant women (p < 0.01). Women with gestational diabetes had significantly higher mean CGM-glucose (mean +/- SEM 5.6 +/- 0.01 Vs 5.4 +/- 0.01mmol/l;p < 0.01), significantly altered time-below- range (median(IQR);1.0% (0.2-2.9) vs 2.5% (0.7-5.5);p < 0.05) and time-in- range (95.0% (91.1-97.9) vs 94.5% (87.9-96.2);p < 0.05) but comparable time-above- range to healthy women with risk factors. Diurnal glucose profiles in women with gestational diabetes were comparable to healthy women between 14:00 and 18:00, but demonstrated significant increases in glucose at all other time points during the 24-h cycle (p < 0.01). Conclusion(s): Mean CGM glucose is the most reliable CGM metric to distinguish women with gestational diabetes from healthy pregnant women with risk factors.

The impact of the COVID-19 pandemic on the provision & utilisation of primary health care services in Goma, Democratic Republic of the Congo, Kambia district, Sierra Leone & Masaka district, Uganda.

INTRODUCTION: This study aimed to determine whether the COVID-19 pandemic had an impact on essential primary healthcare services at public primary healthcare facilities. METHODS: The number of weekly consultations for antenatal care (ANC), outpatient (OPD), immunisations (EPI), family planning (FP) and HIV services, between January 2018 and December 2020, were collected from 25 facilities in Masaka district, Uganda, 21 in Goma, and 29 in Kambia district, Sierra Leone. Negative binomial regression models accounting for clustering and season were used to analyse changes in activity levels between 2018, 2019 and 2020. RESULTS: In Goma, we found no change in OPD, EPI or ANC consultations, FP was 17% lower in March-July 2020 compared to 2019, but this recovered by December 2020. New diagnoses of HIV were 34% lower throughout 2020 compared to 2019. In Sierra Leone, compared to the same periods in 2019, facilities had 18-29% fewer OPD consultations throughout 2020, and 27% fewer DTP3 doses in March-July 2020. There was no evidence of differences in other services. In Uganda there were 20-35% fewer under-5 OPD consultations, 21-66% fewer MCV1 doses, and 48-51% fewer new diagnoses of HIV throughout 2020, compared to 2019. There was no difference in the number of HPV doses delivered. CONCLUSIONS: The level of disruption varied across the different settings and qualitatively appeared to correlate with the strength of lockdown measures and reported attitudes towards the risk posed by COVID-19. Mitigation strategies such as health communications campaigns and outreach services may be important to limit the impact of lockdowns on primary healthcare services.

Resident Perceptions and Confidence Regarding Pediatric Preventive Care

Purpose of Study: Residents have experienced changes in educational structure, format, content, and patient experience due to the COVID-19 pandemic. Resident physicians across the country have reported changes in workload including a decrease in well child checks and immunizations resulting in limited clinical exposure. This study aimed to assess the confidence of first year pediatric residents (interns) in conducting routine preventive screening for children and to identify potential gaps in knowledge among this cohort. Methods Used: We conducted a cross-sectional observation study that included 13 categorical first year pediatric residents. A voluntary, anonymous online survey was administered in September 2022. The survey assessed confidence levels, and perceived comfort regarding common preventive pediatric encounters and screening tools. The survey included 7-questions based on the 4th Edition Bright Future's Guidelines and respondents rated their answers on a 5-point Likert scale. The surveys were distributed anonymously via e-mail using Survey Monkey, a web-based software platform that provided an intuitive interface for validated data capture. Participants were given 2 weeks to complete the survey and reminders were sent via email. Summary of Results: Eight of 13 interns participated for a response rate of 62%. Sixty-three percent of the residents had completed a subinternship in pediatrics. Of our respondents, 75% reported feeling "not at all confident" in executing well child check-ups for children <12months old and 63% reported feeling "very confident" in examining children> 13months old. Regarding the ability to perform a genitourinary examination in children >12years of age, 63% of respondents stated that they were "slightly" or "not at all confident". We asked interns to rate their confidence in providing anticipatory guidance to their patients. Interns perceived being somewhat confident regarding guidance about safe sex, tobacco use, and healthy lifestyles but less confident regarding newborn care, breast feeding and infant nutrition. Nearly 40% reported comfort in recommending and advising parents about the risks and benefits of age appropriate immunizations. We asked residents to report their ability in administering and interpreting screening tools (ASQ, MCAT, EPDS). Interns reported that were able to interpret results but lacked confidence in providing guidance. Conclusion(s): Our study identifies opportunities to bridge experiential knowledge gaps and confidence among pediatric interns who may have had limited clinical exposure to pediatrics following the COVID-19 pandemic. Graduate medical education programs should consider developing tailored educational interventions specifically geared for identified learning gaps to mitigate the challenges posed by the pandemic.

Comparison of thrombus burden in patients with COVID-19 presenting with ST-segment elevation myocardial infarction across the three waves of outbreak in the United Kingdom

Background: It has been previously reported during the first COVID outbreak that patients presenting with ST-Segment Elevation Myocardial Infarction (STEMI) and concurrent COVID-19 infection have increased thrombus burden and poorer outcomes [1]. Subsequently, there have been multiple further waves of the pandemic with the emergence of at least two new COVID-19 variants and the emergence of vaccinations. To-date, there have been no reports comparing the outcomes of COVID-19-positive STEMI patients across all waves of the pandemic. Purpose(s): The purpose of this study was to compare the baseline demographic, procedural and angiographic characteristics alongside the clinical outcomes of patients presenting with STEMI and concurrent COVID-19 infection across the COVID-19 pandemic in the UK. Method(s): This was a single-centre, observational study of 1250 consecutive patients admitted with confirmed STEMI treated with primary percutaneous coronary intervention (PCI) at Barts Heart Centre between 01/03/2020 and 10/03/2022. COVID +ve patients were split into 3 groups based upon the time course of the pandemic (Wave 1: March 2020-June 2020, Wave 2: Sept 2020-March 2021, Wave 3: October 2021-March 2022). Comparison was made between waves and with a control group of COVID-ve patients treated during the same timeframe. Result(s): A total of 135 COVID +ive patients with STEMI (1st Wave: 39 patients, 2nd Wave: 60 patients, 3rd wave 35 pts) were included in the present analysis;and compared with 1115 COVID negative patients. Significant changes in the baseline characteristics, angiographic features and clinical outcomes of COVID +ive patients occurred over time. Early during the pandemic (Wave 1 2020), STEMI patients presenting with concurrent COVID-19 infection had high rates of cardiac arrest, evidence of increased thrombus burden (higher rates of multi-vessel thrombosis, stent thrombosis, higher modified thrombus grade higher use of GP IIb/IIIa inhibitors and thrombus aspiration, coagulability (more heparin for therapeutic ACT), bigger infarcts (lower myocardial blush grade and left ventricular function) and worse outcomes (mortality). However, by wave 3 (late 2021/2022), no differences existed in clinical characteristics, thrombus burden, infarct size or outcomes between COVID +ive patients and those without concurrent COVID-19 infection with significant differences compared to earlier COVID +ve patients. Poor outcomes later in the study period were predominantly in unvaccinated individuals. Conclusion(s): Significant changes have occurred in the clinical characteristics, angiographic features and outcomes of STEMI patients with COVID- 19 infection treated by primary PCI during the course of the pandemic. Importantly it appears that angiographic features and outcomes of recent waves are no different to a non-COVID-19 population.

Utilizing Mobile Diabetic Foot Clinics To Provide Comprehensive Care To Patients Experiencing Homelessness

Introduction and Objectives: Limited healthcare access and resource inequities pose significant barriers to care, all of which have been amplified during the COVID-19 pandemic. DFUs represent an especially challenging medical problem to prevent and treat due to the resource intensive care required. We sought to evaluate the feasibility of multidisciplinary, mobile, DFU outreach clinics to improve access to care. Method(s): Our clinic model focused on creating mobile diabetic foot clinics staffed by volunteer clinical providers who specialize in Vascular Surgery, Diabetes, and Podiatry. We recruited volunteer healthcare providers from an academic medical center. We partnered with local community centers with established programs providing services to unhoused individuals. Result(s): Between June 2020 and August 2022, a total of 130 unhoused individuals were seen at four mobile clinics set up at different locations. Diabetic foot care was provided by volunteers from seven departments: Endocrinology/Diabetes, Vascular Surgery and Vascular Lab, Podiatry, Addiction Medicine, Smoking Cessation, and Financial. On average, 32 healthcare provider volunteers participated at each clinic. Services provided include: vitals, blood glucose, HgA1c, lipid panel testing, ankle-brachial index, podiatric exam, wound care, medical education, COVID vaccination/booster, insurance enrollment, and new socks and shoes. Of 130 unhoused patients, 29% had hypertension (38), 34% had abnormal ABI (44), and 14% had diabetes (18). Fifteen patients were further identified as high risk for developing DFU-associated amputation (12%) and were provided with ambulatory follow-ups. Conclusion(s): In our pilot experience, it is feasible to provide consistent comprehensive DFU care through mobile outreach clinics. By using the infrastructure of partner organizations and healthcare expertise of an academic center, our clinics could integrate into existing community services. [Formula presented]Copyright © 2022

Clinical presentations and management of COVID-19 infected children seen in a district health facility in Kambia, northern Sierra Leone

Studies reporting the clinical presentations of COVID-19 in children in sub-Saharan Africa are few, especially from resource-constrained countries. This case series reports the demographic and clinical characteristics and laboratory findings of confirmed cases of COVID-19 in children seen at a district hospital in Sierra Leone. This is a report of nine COVID-19 paediatric cases managed at a secondary level hospital in Kambia District, Northern Sierra Leone. Each child was detected by contact tracing after an infected adult was identified by the COVID-19 response team. The clinical symptoms at presentation, clinical courses, and treatments instituted and patient outcomes are discussed in the context of the facilities available at a typical West African district hospital. Nine out of 30 individuals with confirmed COVID-19 infection who presented to the hospital from 24 April to 20 September 2020 and who were admitted to the isolation center of the hospital were in the paediatric age group. The mean age (SD) and median (IQR) of the children were 69.0 +/- 51.7months and 84.0 (10.5, 108.0) months, respectively;five (55.6%) were males. The children were asymptomatic or only had mild illnesses and none required intranasal oxygen or ventilatory support. In the five symptomatic children, the most common symptoms were fever (40%) and cough (40%). All children had normal haemoglobin, platelet and white blood cell (WBC) count. Four children had a positive malaria test and were treated with a complete course of anti-malaria medications. No child received steroid or had specific anti-COVID-19 treatment. All children stayed in the isolation center for 14 days and were re-tested for COVID-19 two weeks after initial diagnosis. No complications have been reported in any of them since discharge. The proportion of children among COVID-19 infected cases seen in a rural community in Sierra Leone was 30%. Fever was the most common symptom and malaria was confirmed in 40% of the infected children. This has significant implication on the diagnosis of COVID-19 in malaria-endemic settings and on how best to manage children who present with fever during the COVID-19 pandemic. Copyright © Hammed Hassan Adetola et al.

The Clinical Effectiveness of Dynamic Electronic Tracking and Escalation to Reduce Critical Care Transfers (the Detect Study)

BACKGROUND AND AIM: Physiological surveillance systems significantly reduced adult mortality in two large UK hospitals. In hospitalised children mortality is low, but there may be potential to reduce the morbidity associated with critical deterioration (CD). However, the risk models for adults are unsuitable for use in children because the signs associated with deterioration [heart rate, breathing rate, blood pressure], alter significantly across the age range. The aim is to evaluate whether this technology improves clinical outcomes for in-hospital deterioration, including sepsis in children. METHOD(S): ISRCTN61279068. https://bit.ly/36HtEGF Participants: Paediatric in-patients, aged less than 18 years at a tertiary hospital (240 beds). Intervention(s): Careflow Vitals and Connect app platform configured to incorporate the Alder Hey age-specific Paediatric Early Warning score (PEWS) and modified National Institute of Health and Clinical Excellence (NICE) Sepsis screening. The documentation of vital signs and clinical observations occur at the patient's bedside at intervals determined by the PEWS risk model. PEWS categorised CD risk as low, moderate, high and critical and provided targeted escalation advice and automated alerts to the Nurse in Charge of the shift and the responsible Clinical Teams. Primary Outcome:Emergency transfers to Critical Care (PICU/ HDU). RESULT(S): Prospective data collection baseline year March 2018 - February 2019 compared with 2 years postintervention March 2020-February 2022 (Extended due to COVID). Summary of results in Figure 1. CONCLUSION(S): The absolute number of CD and patients affected reduced by 29%. Associated review of the cases using the Predictability/Preventability framework showed reduction in the late recognition and CD with modifiable factors. (Figure Presented).

Factors associated with response to a phone-administered alcohol and substance use survey during the COVID-19 pandemic among women in the MACS/WIHS Combined Cohort Study: Who are we missing?

Background. Early in the COVID-19 pandemic, many clinical studies pivoted to remote research visits, which have a higher non-response rate compared to in-person assessments. Survey non-response can bias estimates of alcohol and substance use prevalence. Our objective was to identify factors associated with responding to an alcohol and substance use phone survey administered during the COVID-19 pandemic to women enrolled in the MACS/WIHS Combined Cohort Study, a multicenter U.S. prospective cohort of adults living with and without HIV. Methods. We assessed associations of pre-pandemic (April-Sept. 2019) sociodemographic factors, HIV status, housing status, depressive symptoms, alcohol use, and substance use measures with response to a pandemic (Aug.-Sept. 2020) phone survey using multivariable logistic regression. Response probability weights generated from the regression model were applied to the sample and prevalence estimates of risky drinking (> 7 drinks/week or > 3 drinks/day) and substance use (opioids, stimulants, sedatives) in the COVID-19 pandemic were compared to the unweighted sample. Results. Of 1,834 women with pre-pandemic data, 62% were of Black race, 46% had an annual income < $12K, 71% were living with HIV and the mean age was 52.4 (SD 9.3) years. The phone survey response rate was 77.5%. In the adjusted model, the odds of responding were lower at research sites in the Western (aOR 0.35 95% CI 0.21-0.57) and Southern US (aOR 0.29 95% CI 0.19-0.44, ref=Midwest), in women of Hispanic ethnicity (aOR 0.47 95% CI 0.33-0.66, ref=Black race), and in those who reported substance use (aOR 0.62 95% CI 0.40-0.95). By contrast, the odds were higher for women of white race (aOR 1.63 95% CI 1.02-2.70) and those with stable housing (aOR 1.71 95% CI 1.22-2.39). Un weighted versus weighted prevalence estimates were 11.1% vs. 11.6% for risky drinking and 6.1% vs. 6.9% for substance use. Conclusion. Among a sample of socioeconomically disadvantaged women, women of Hispanic ethnicity, and those who were unstably housed and reported substance use at baseline had lower odds of responding to an alcohol and substance use phone survey conducted early in the COVID-19 pandemic. As remote survey methods become more common, investigators should ensure that data remain representative of the target population.

The Effects of Modified Personal Protective Equipment (PPE) Protocols on Healthcare Personnel Providing Patient Care During the COVID-19 Pandemic: A Qualitative Assessment

Background. Healthcare personnel (HCP) faced personal protective equipment (PPE)-related challenges during the COVID-19 pandemic including supply shortages, additional PPE items, different designs, and modified protocols (PR)/guidelines. We used a human factors engineering- and ethnography-informed approach to qualitatively assess the effects of these challenges on HCP and their PPE use during the pandemic. Methods. We observed PPE use (e.g., donning/doffing) by HCP caring for patients with COVID-19, those under investigation (PUI), and those with other conditions in 1 acute, 1 intermediate, and 1 intensive care unit at a large Midwestern academic hospital. We conducted mini-interviews with a subset of HCP to clarify observed behavior and identify PPE-related concerns. We captured observation, interview, and additional data (e.g., unit layouts, signage) in structured and unstructured notes. We transcribed and imported notes into MAXQDA and applied a deductive-inductive analytical approach. Results. From April-July 2021, we observed 188 patient care episodes and conducted 47 mini-interviews. Observations included COVID-19 (n=102), PUI (n=4), and non-COVID-19 (n=82) rooms on varying isolation precautions. PRs related to masks and eye protection changed during the study period and particularly affected donning practices. Other barriers included time-intensive PRs, unclear PR communication, unfamiliar designs, lack of surfaces on which to set supplies while donning/ doffing, and inconvenient PPE storage/cleaning locations. We observed recommendation/ PR deviations related to PPE use (e.g., exposed wrists, unapproved/no eye protection), cleaning, and signage/storage (e.g., designated 'clean' surfaces). HCP reported PPE extended use/reuse, provision of design options, and their own adaptations (e.g., 'batching' tasks, modifying PPE) facilitated donning/doffing. New PPE requirements highlighted tensions between HCP comfort and safety;despite this, some wanted to include modified PRs in their routine infection prevention practices permanently. Conclusion. PPE use barriers and facilitators related to modified COVID-19 PRs have implications for the ongoing pandemic and future respiratory pathogen outbreaks.

BU-TTS: An Open-Source, Bilingual Welsh-English, Text-to-Speech Corpus

This paper presents the design, collection and verification of a bilingual text-to-speech synthesis corpus for Welsh and English. The ever expanding voice collection currently contains almost 10 hours of recordings from a bilingual, phonetically balanced text corpus. The speakers consist of a professional voice actor and three amateur contributors, with male and female accents from north and south Wales. This corpus provides audio-text pairs for building and training high-quality bilingual Welsh-English neural based TTS systems. We describe the process by which we created a phonetically balanced prompt set and the challenges of attempting to collate such a dataset during the COVID-19 pandemic. Our initial findings in validating the corpus via the implementation of a state-of-the-art TTS models are presented. This corpus represents the first open-source Welsh language corpus large enough to capitalise on neural TTS architectures. © European Language Resources Association (ELRA)

Cell-based high throughput screening to identify FDA/ EMA approved drugs that inhibit the endothelial pro-thrombotic switch during severe COVID19 infection

Background: A major complication of COVID19 is severe endothelial injury with micro-and macro-thrombotic disease in the lung and other organs. Several studies have identified high levels of inflammatory cytokines ( cytokine storm ), powerful activators of the endothelium, in plasma of severe COVID19 patients;indeed, COVID19 plasma was shown to activate endothelial cells (EC) in vitro. A consequence of EC activation is loss of anti-coagulant function, with release of pro-thrombotic Von Willebrand Factor (VWF). High levels of plasma VWF in severe COVID19 patients indicate systemic endothelial activation and increased risk of thrombosis. Aim(s): To identify drugs that decrease endothelial activation and VWF release, which may have a therapeutic impact in COVID19 patients. Method(s): We established an in vitro model of endothelial activation driven by 6 cytokines selected because of their high levels in COVID19 plasma. Cells were treated with the 6-cytokine cocktail for 24 hr;endothelial activation was confirmed by a panel of markers including ICAM1, measured by RT-qPCR and immunofluorescence (IF). Result(s): The treatment induced release of VWF and increased VWF-platelet string formation in a platelet flow-based assay. To identify drugs that blocked cytokine-induced VWF release, a high-throughput screening was carried out in human umbilical vein EC (HUVEC);VWF and ICAM1 expression were detected by IF;DAPI was used as nuclear stain. High content imaging screen of 3049 drugs from FDA/EMA-approved drug libraries identified drugs able to decrease VWF release following cytokine treatment. Top hits from several therapeutic classes including anti-inflammatory, anti-viral and hormones were taken forward for validation. Two hits were confirmed to inhibit cytokine-induced VWF release and VWF-platelet string formation. Selected findings were validated in lung microvascular EC. Conclusion(s): This study identified candidate drugs that reduce the enhanced VWF release caused by the cytokine storm typical of severe COVID19;these may be beneficial in the treatment of the pro-thrombotic risk in COVID19 patients.

A novel classification of obstructive sleep apnoea enabling precision medicine to improve adherence to continuous positive airway pressure: A growth mixture modelling analysis

Introduction: High non-adherence rates to CPAP remain a major obstacle to good outcomes in OSA. In trials, 29%-83% of patients do not adhere to CPAP. CPAP adherence in clinical practice, and the effect of clinical pathways and interventions, remain unknown because of incomplete datasets and use of non-clinically relevant criteria for adherence in previous studies. Patients are reported to become adherent or non-adherent to CPAP from treatment onset, forming the basis of current clinical practice, but the studies have been small. We addressed these evidence gaps using a large, UK multicentre clinical dataset, using changes to sleep centres' treatment pathways during the COVID-19 pandemic as a natural experiment. Method(s): Five sleep centres that telemonitored patient data in 2019 and 2020 were recruited. Using a 18% difference in CPAP adherence between years (Philips Respironics data), 80% power, alpha < 0.05, n = 92 was required. Objective CPAP-usage data over the first three months of treatment was collected from 100 patients who started CPAP prepandemic (April 2019) and 100 patients post-start of pandemic (September 2020), per centre. CPAP adherence criteria: Mean CPAP use >=4 h/night for >=70% of nights (for Night 1-3 period, median CPAP use used, as data non-normally distributed). Growth mixture modelling (GMM) and logistic regression were performed using all centres' data (1000 patients). Result(s): Three months after treatment started, only 34% of patients were treatment-adherent in 2019 and 42% in 2020 (p = 0.24). GMM identified six distinct, CPAP-usage behaviours over the first month, each with a different likelihood of CPAP non-adherence at three months. Four behaviours consisted of changing (increasing or decreasing) CPAP use (54% of patients), two behaviours consisted of consistent good or no use (remaining 46%). Treatment pathway determined prevalence of behaviours and CPAP adherence at three months;OSA severity was a weaker determinant of CPAP adherence at three months. Conclusion(s): CPAP use at treatment onset does not predict long-term adherence in most patients. This can explain why current practice is ineffective, and may even be detrimental, as the changing users are inappropriately managed as consistent users . Our data supports precision medicine tailored to specific behaviour from Week 2 of treatment.

CORD COVID-19 Task Forces Report on the Pandemic Impacts on Undergraduate Medical Education

Learning Objective: We sought to describe the effects of COVID-19 on UME within EM. Background(s): The COVID-19 pandemic has affected multiple aspects of Undergraduate Medical Education (UME) beyond infection and illness. Many universities, medical schools, and hospitals instituted policy changes around educational gatherings and clinical participation. State-issued travel restrictions impacted both rotations and altered the Match process. Objective(s): We sought to describe the effects of COVID-19 on UME within EM. Method(s): CORD chartered a COVID-19 Task Force comprised of 18 selected educators to explore the pandemic's impact on EM. A Modified Delphi process was used to develop multiple survey instruments. This process included a literature search for validated questions and internal piloting with iterative changes. After IRB approval, the UME survey was distributed to members of CORD during the 2021 Academic Assembly. Using SPSS v26, a descriptive analysis was performed. Result(s): Sixty-three individuals responded to the UME survey, with 27 (42.9%) program directors (PDs), 19 (30.2%) assistant/associate PDs, 5 (7.9%) core faculty, 5 (7.9%) clerkship directors, 4 (6.3%) residents/fellows and 3 others (vice chair of education, educational researcher, unknown). Most respondents were white (84.1%) and approximately half identified as women (50.8%). Table 1 provides means and standard deviations for statements displayed from most to least important. Conclusion(s): The positive financial impact on medical students was described as the greatest benefit of the pandemic. Virtual technology was varied in its impact: positive for conferences and interviewing but negative as a surrogate for clinical rotations or the ability for students to evaluate residency program culture. The top challenge facing UME was the removal of students from clinical rotations. This may impact residency programs, requiring them to remediate those skills. A limitation of this geographically broad cohort was the number of respondents.

CORD COVID-19 Task Force Report on the Pandemic Impact on Undergraduate Medical Education

Learning Objectives: We sought to describe the effects of COVID-19 on UME within EM. Background(s): The COVID-19 pandemic has affected multiple aspects of Undergraduate Medical Education (UME) beyond infection and illness. Many universities, medical schools, and hospitals instituted policy changes around educational gatherings and clinical participation. State-issued travel restrictions impacted both rotations and altered the Match process. Objective(s): We sought to describe the effects of COVID-19 on UME within EM. Method(s): CORD chartered a COVID-19 Task Force comprised of 18 selected educators to explore the pandemic's impact on EM. A Modified Delphi process was used to develop multiple survey instruments. This process included a literature search for validated questions and internal piloting with iterative changes. After IRB approval, the UME survey was distributed to members of CORD during the 2021 Academic Assembly. Using SPSS v26, a descriptive analysis was performed. Result(s): Sixty-three individuals responded to the UME survey, with 27 (42.9%) program directors (PDs), 19 (30.2%) assistant/associate PDs, 5 (7.9%) core faculty, 5 (7.9%) clerkship directors, 4 (6.3%) residents/fellows and 3 others (vice chair of education, educational researcher, unknown). Most respondents were white (84.1%) and approximately half identified as women (50.8%). Table 1 provides means and standard deviations for statements displayed from most to least important. Conclusion(s): The positive financial impact on medical students was described as the greatest benefit of the pandemic. Virtual technology was varied in its impact: positive for conferences and interviewing but negative as a surrogate for clinical rotations or the ability for students to evaluate residency program culture. The top challenge facing UME was the removal of students from clinical rotations. This may impact residency programs, requiring them to remediate those skills. A limitation of this geographically broad cohort was the number of respondents.

Impact of the COVID-19 Pandemic on US Emergency Medicine Education: A Needs Assessment for Academic Emergency Medicine Faculty

Learning Objective: To characterize the challenges and benefits that the COVID-19 pandemic has provided to academic EM faculty. Background(s): The COVID-19 pandemic has presented unpredicted challenges to EM education. The speed of the pandemic and extraordinary clinical burden prevented a coordinated educational response at all levels, including that of faculty development. While COVID-19 research is prolific and ongoing, EM faculty educational impact is yet to be fully explored. Objective(s): To characterize the challenges and benefits that the COVID-19 pandemic has provided to academic EM faculty. Method(s): CORD chartered a COVID-19 Task Force of 18 selected educators to explore the pandemic's impact on EM. A Modified Delphi process was used to develop multiple survey instruments. This process included a literature search for validated questions and internal piloting with iterative changes. After IRB approval, the faculty survey was distributed to members of CORD during the 2021 Academic Assembly. Using SPSS v26, a descriptive analysis was performed. Result(s): Forty-one individuals responded to the survey concerning faculty. Eighteen (43.9%) respondents were program directors, 14 (34.1%) were assistant/associate program directors, four (9.8%) were core faculty, four (9.8%) were clerkship directors, and one individual (2.4%) was involved with faculty development and research. Most respondents were white (87.8%) and women (61%). Table 1 demonstrates the faculty responses for the benefits and challenges of COVID-19 to education. Table 2 notes the impact on the faculty themselves. Conclusion(s): While the educational response to the pandemic was felt by faculty to be positive in the utilization of virtual platforms, faculty felt less engaged and less connected. Personally, faculty reported benefitting from numerous sources of human support, including familial, professional, and public. Despite this support, faculty reported the pandemic left them stressed, distressed, and burned out. A limitation of this geographically broad cohort was the number of respondents.

City-wide wastewater genomic surveillance through the successive emergence of SARS-CoV-2 Alpha and Delta variants.

Genomic surveillance of SARS-CoV-2 has provided a critical evidence base for public health decisions throughout the pandemic. Sequencing data from clinical cases has helped to understand disease transmission and the spread of novel variants. Genomic wastewater surveillance can offer important, complementary information by providing frequency estimates of all variants circulating in a population without sampling biases. Here we show that genomic SARS-CoV-2 wastewater surveillance can detect fine-scale differences within urban centres, specifically within the city of Liverpool, UK, during the emergence of Alpha and Delta variants between November 2020 and June 2021. Furthermore, wastewater and clinical sequencing match well in the estimated timing of new variant rises and the first detection of a new variant in a given area may occur in either clinical or wastewater samples. The study's main limitation was sample quality when infection prevalence was low in spring 2021, resulting in a lower resolution of the rise of the Delta variant compared to the rise of the Alpha variant in the previous winter. The correspondence between wastewater and clinical variant frequencies demonstrates the reliability of wastewater surveillance. However, discrepancies in the first detection of the Alpha variant between the two approaches highlight that wastewater monitoring can also capture missing information, possibly resulting from asymptomatic cases or communities less engaged with testing programmes, as found by a simultaneous surge testing effort across the city.

Efficacy and safety of 2 doses of onabotulinumtoxin A for the treatment of masseter muscle prominence: 6-month results from a randomized, phase 2b placebo-controlled study

Purpose: Evaluate efficacy and safety of onabotulinumtoxin A compared with placebo for treating masseter muscle prominence (MMP). Methods: Adults with bilateral grade 4 (Marked) or 5 (Very marked) MMP on the 5-grade clinician-assessed MMP Scale (MMPS) received onabotulinumtoxinA 72 U, 48 U, or placebo. Primary efficacy endpoint was participants achieving MMPS grade ≤3 at day 90. Participants with grade ≤3 for the MMPS and Participant MMPS (MMPS-P), and participants achieving grade ≥2 in the Participant Self-Assessment of Change (PSAC), were evaluated until day 180. Results: Of 150 participants randomized, 34 (22.7%) discontinued (12 [8.0%] due to COVID-19). The modified intent-to-treat population included 145 participants (mean age, 39.3 years;mean BMI, 24.1 kg/m2;89.7% female;75.9% White). MMPS and MMPS-P responder rates were higher for onabotulinumtoxinA 72 U and 48 U than placebo at days 90 (MMPS: 91.3% and 90.6% vs 21.7%;MMPS-P: 93.5% and 96.2% vs 47.8%;both P <.0001) and 180 (MMPS: 71.7% and 56.6% vs 26.1%;MMPS-P: 87.0% and 86.8% vs 60.9%;both P <.01). More onabotulinumtoxinA 72 U and 48 U participants achieved PSAC grade ≥2 than placebo at days 90 (73.9% and 90.6% vs 21.7%;P <.0001) and 180 (76.1% and 66.0% vs 28.3%;P <.001). Treatment-related adverse events occurred in onabotulinumtoxinA 72 U and 48 U groups (12.2% and 9.4%) vs none in placebo;the majority were mild in severity. Conclusion: A single treatment of onabotulinumtoxinA (72 U and 48 U) reduced MMP and improved lower face contour for up to 6 months. Both dose groups demonstrated favorable safety profiles.